Ras Antibody from MYBIOSOURCE INC.
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| Edit | |
|---|---|
| Antigenic Specificity | Ras |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, mouse, rat |
| Isotype | n/a |
| Format | affinity purified |
| Size | 0.1 mL, 0.2 mL |
| Concentration | n/a |
| Applications | Western Blot (WB), Immunoprecipitation (IP), Flow Cytometry (FC/FACS) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | The 21 kDa guaninenucleotide binding proteins (K-Ras, H-Ras and N-Ras) cycle between active (GTPbound) and inactive (GDPbound) forms (1). Receptor tyrosine kinases and Gproteincoupled receptors activate Ras, which then stimulates the Raf-MEK-MAPK pathway (2-4). GTPaseactivating proteins (GAP) normally facilitate the inactivation of Ras. However, in 30% of human tumors, point mutations in Ras prevent the GAPmediated inhibition of this pathway (5). The most common oncogenic Ras mutation found in tumors is Gly12 to Asp (G12D), which prevents Ras inactivation, possibly by increasing the overall rigidity of the protein (5,6). |
| Immunogen | Immunogen: A synthetic -peptide of human Ras |
| Other Names | [NRAS; Ras; Ras; NRAS; ALPS4; Nras; NRAS1; NS6; GTPase NRas; Transforming protein NRas;], [NRAS; NRAS; NS6; ALPS4; N-ras; NRAS1; HRAS1] |
| Gene, Accession # | Gene ID: 4893, NCBI: NP_002515.1, UniProt: P01111 |
| Catalog # | MBS125242 |
| Price | $275, $430 |
| Order / More Info | Ras Antibody from MYBIOSOURCE INC. |
| Product Specific References | 1. Boguski, M.S. and McCormick, F. (1993) Nature 366, 643-654. 2. Avruch, J. et al. (1994) Trends Biochem. Sci. 19, 279-283. 3. Buday, L. and Downward, J. (1993) Cell 73, 611-620. 4. Huang, D.C. et al. (1993) Mol. Cell Biol. 13, 2420-2431. 5. Bos, J.L. (1989) Cancer Res. 49, 4682-4689. 6. Ma, J. and Karplus, M. (1997) J. Mol. Biol. 274, 114-131. |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
sales@mybiosource.com
http://www.MyBioSource.com
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