Edit |   |
Antigenic Specificity | Rat VEGF-C |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | rat |
Isotype | n/a |
Format | Protein A purified |
Size | 0.1 mg |
Concentration | n/a |
Applications | Western Blot (WB), ELISA (EIA), Immunoprecipitation (IP) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | VEGF-C, a member of the VEGF/PDGF family of structurally related proteins, is a potent angiogenic cytokine. It promotes endothelial cell growth, promotes lymphangiogesis, and can also affect vascular permeability. VEGF-C is expressed in various tissues, but is not produced in peripheral blood lymphocytes. It forms cell surfaced-associated non-covalent disulfide linked homodimers, and can bind and activate both VEGFR-2 (flk1) and VEGFR-3 (flt4) receptors. During embryogenesis, VEGF-C may play a role in the formation of the venous and lymphatic vascular systems. Both VEGF-C and VEGF-D are over-expressed in certain cancers, and the resulting elevated levels of VEGF-C or VEGF-D tend to correlate with increased lymphatic metastasis. Recombinant, |
Immunogen | Immunogen: Recombinant rat VEGF-C (RT #R20-015). Preparation: Produced from sera of rabbits pre-immunized with highly pure recombinant rat VEGF-C (Asp101-Ile221) derived from insect cells. |
Other Names | [rat Vascular Endothelial Growth Factor-C; VRP; Flt4-L; VEGF-relazted protein], [Vegfc; Vegfc; VEGF-C; Flt4-L; VRP] |
Gene, Accession # | [VEGF-C], Gene ID: 114111, NCBI: NP_005420.1, UniProt: P49767 |
Catalog # | MBS691452 |
Price | $255 |
Order / More Info | Rat VEGF-C Antibody from MYBIOSOURCE INC. |
Product Specific References | 1. Joukov et al., EMBO J 15:290, 1996 2. Olofsson et al., Curr Opin Biotech 10:528, 1999 3. Kukk et al., Development 122:3829, 1996 |