Edit |   |
---|---|
Antigenic Specificity | MKI67 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | affinity purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | Western Blot (WB), Immunofluorescence (IF) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). Associates with the surface of the mitotic chromosome, the perichromosomal layer, and covers a substantial fraction of the chromosome surface (PubMed:27362226). Prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes. May play a role in c |
Immunogen | Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1200-1300 of human MKI67 (NP 001139438.1). |
Other Names | [KIA; MIB-; MIB-1; PPP1R105] |
Gene, Accession # | [MKI67], Gene ID: 4288, NCBI: NP_001139438.1, UniProt: P46013 |
Catalog # | MBS8544791 |
Price | $280 |
Order / More Info | MKI67 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |