Phospho-MTOR-S2448 Antibody from MYBIOSOURCE INC.
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|---|---|
| Antigenic Specificity | Phospho-MTOR-S2448 |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, mouse, rat |
| Isotype | n/a |
| Format | affinity purified |
| Size | 0.05 mL, 0.1 mL, 0.2 mL |
| Concentration | 1mg/ml |
| Applications | Western Blot (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | The mammalian target of rapamycin (mTOR, FRAP, RAFT) is a Ser/Thr protein kinase (1-3) that functions as an ATP and amino acid sensor to balance nutrient availability and cell growth (4,5). When sufficient nutrients are available, mTOR responds to a phosphatidic acid-mediated signal to transmit a positive signal to p70 S6 kinase and participate in the inactivation of the eIF4E inhibitor, 4E-BP1 (6). These events result in the translation of specific mRNA subpopulations. mTOR is phosphorylated at Ser2448 via the PI3 kinase/Akt signaling pathway and autophosphorylated at Ser2481 (7,8). mTOR plays a key role in cell growth and homeostasis and may be abnormally regulated in tumors. For these reasons, mTOR is currently under investigation as a p |
| Immunogen | Immunogen: A phospho specific peptide corresponding to residues surrounding serine 2448 of human mTOR/FRAP |
| Other Names | [Phospho-MTOR-S2448: MTOR; FLJ44809; FRAP; FRAP1; FRAP2; RAFT1; RAPT1], [MTOR; MTOR; FRAP; FRAP1; FRAP2; RAFT1; RAPT1; FRAP; FRAP1; FRAP2; RAFT1; RAPT1; mTOR] |
| Gene, Accession # | [MTOR], Gene ID: 2475, NCBI: P42345.1, UniProt: P42345 |
| Catalog # | MBS126186 |
| Price | $235, $350, $525 |
| Order / More Info | Phospho-MTOR-S2448 Antibody from MYBIOSOURCE INC. |
| Product Specific References | n/a |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
sales@mybiosource.com
http://www.MyBioSource.com
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