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Antigenic Specificity | LKB1 (Phospho-Ser428) |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | epitope affinity purified |
Size | 0.05 mL, 0.1 mL |
Concentration | 1.0 mg/ml |
Applications | Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | The antibody detects endogenous level of LKB1 only when phosphorylated at serine 428. Tumor suppressor serine/threonine-protein kinase that controls the activity of AMP-activated protein kinase (AMPK) family members, thereby playing a role in various processes such as cell metabolism, cell polarity, apoptosis and DNA damage response. Acts by phosphorylating the T-loop of AMPK family proteins, leading to promote their activity: phosphorylates PRKAA1, PRKAA2, BRSK1, BRSK2, MARK1, MARK2, MARK3, MARK4, NUAK1, NUAK2, SIK1, SIK2, SIK3 and SNRK but not MELK. Also phosphorylates non-AMPK family proteins such as STRADA and possibly p53/TP53. Acts as a key upstream regulator of AMPK by mediating phosphorylation and activation of AMPK catalytic subuni |
Immunogen | Immunogen Type: Peptide-KLH Immunogen Description: Peptide sequence around phosphorylation site of serine428 (R-L-S(p)-A-C) derived from Human LKB1. |
Other Names | [Protein kinase; CAMK group; CAMKL family; LKB subfamily] |
Gene, Accession # | [LKB1], Gene ID: 6794, NCBI: NP_000446.1, UniProt: Q15831 |
Catalog # | MBS9407749 |
Price | $200, $255 |
Order / More Info | LKB1 (Phospho-Ser428) Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |