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Antigenic Specificity | Mcl-1 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat, monkey |
Isotype | n/a |
Format | affinity purified |
Size | 0.03 mg, 0.1 mg |
Concentration | 0.2 mg/ml |
Applications | Western Blot (WB), Immunoprecipitation (IP), Immunofluorescence (IF), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Background: Mcl-1 (Myeloid cell leukemia-1) is a 37 kDa Bcl-2-related protein with an apparent molecular weight of 43 kDa on SDS-PAGE. Mcl-1 was identified as an early-induction gene that increased in expression during the differentiation of human myeloblastic leukemia cell ML-1, or exposure to different DNA damaging agents. The level of Mcl-1 is decreased in peripheral B lymphocytes undergoing apoptosis following treatment with apoptotic stimuli such as TGF-beta1 and forskolin. Expression of Mcl-1 is able to delay apoptosis induced by over-expression of c-myc in CHO 5AHSmyc cells. In hematopoietic FDC-P1 cells, Mcl-1 interacts with another Bcl-2-related protein, Bax, and prolongs cell viability after treatment with different apoptotic reag |
Immunogen | Immunogen: Synthetic peptide corresponding to residues surrounding amino acid 131 of human Mcl-1 |
Other Names | [MCL1L; mcl1/EAT; MGC1839; MGC104264; TM; MCL1S; EAT], [MCL1; MCL1; TM; EAT; MCL1L; MCL1S; Mcl-1; BCL2L3; MCL1-ES; bcl2-L-3; mcl1/EAT; BCL2L3; Bcl2-L-3] |
Gene, Accession # | [Mcl-1], Gene ID: 4170, NCBI: NP_001184249.1, UniProt: Q07820 |
Catalog # | MBS841378 |
Price | $150, $290 |
Order / More Info | Mcl-1 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |