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Antigenic Specificity | STUB1 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | Protein G purified |
Size | 0.05 mg, 0.1 mg |
Concentration | n/a |
Applications | ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | E3 ubiquitin-protein ligase which targets misfolded chaperone substrates towards proteasomal degradation. Collaborates with ATXN3 in the degradation of misfolded chaperone substrates: ATXN3 restricting the length of ubiquitin chain attached to STUB1/CHIP substrates and preventing further chain extension. Ubiquitinates NOS1 in concert with Hsp70 and Hsp40. Modulates the activity of several chaperone complexes, including Hsp70, Hsc70 and Hsp90. Mediates transfer of non-canonical short ubiquitin chains to HSPA8 that have no effect on HSPA8 degradation. Mediates polyubiquitination of DNA polymerase beta (POLB) at 'Lys-41', 'Lys-61' and 'Lys-81', thereby playing a role in base-excision repair: catalyzes polyubiquitination by amplifying the HUWE1 |
Immunogen | Immunogen: Recombinant Human E3 ubiquitin-protein ligase CHIP protein (1-48AA) |
Other Names | [E3 ubiquitin-protein ligase CHIP; Antigen NY-CO-7; STUB1] |
Gene, Accession # | [STUB1], Gene ID: 10273, NCBI: NP_001280126.1, UniProt: Q9UNE7 |
Catalog # | MBS7051600 |
Price | $160, $235 |
Order / More Info | STUB1 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |