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Antigenic Specificity | Caspase-12 (NT) (involved in Alzheimers) |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | immunoaffinity purified |
Size | 0.1 mg |
Concentration | n/a |
Applications | Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Three distinct signaling pathways lead to programmed cell death (apoptosis). The death receptor and mitochondrion pathways are the mains, in which the key apoptotic proteases capase-8 and caspase-9, respectively, are involved. The endoplasmic reticulum (ER) stress is the third apoptotic pathway and caspase-12 is involved (1,2). Caspase-12 is localized to the ER but not to cytoplasm or mitochondrion. Caspase-12 is activated by ER stress, including disruption of ER calcium homeostasis, and mediates ER stress-induced apoptosis. Caspase-12 is co-localized to the ER with several proteins that are involved in Alzheimer?s disease including -secretase presenilin and -amyloid precursor protein (APP). Caspase-12 mediates cytotoxicity induced by amylo |
Immunogen | Immunogen: Synthetic peptide corresponding to amino acids 2 to 17 of the murine caspase-12 |
Other Names | [inactive caspase-12; Inactive caspase-12; inactive caspase-12; caspase 12 pseudogene 1; caspase 12 (gene/pseudogene)], [CASP12; CASP12; CASP-12; CASP12P1; CASP-12] |
Gene, Accession # | Gene ID: 100506742, NCBI: NP_001177945.1, UniProt: Q6UXS9 |
Catalog # | MBS395486 |
Price | $510 |
Order / More Info | Caspase-12 (NT) (involved in Alzheimers) Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |