Edit |   |
---|---|
Antigenic Specificity | FCGRT/FcRn (IgG Transporter) |
Clone | [FCGRT/2932] |
Host Species | Mouse |
Reactive Species | human |
Isotype | IgG2b, kappa |
Format | purified |
Size | 0.02 mg (With BSA & Azide at 0.2mg/ml), 0.1 mg (With BSA & Azide at 0.2mg/ml), 0.1 mg (Without BSA & Azide at 1mg/ml) |
Concentration | n/a |
Applications | Immunohistochemistry (IHC) Paraffin |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | This gene encodes a receptor that binds the Fc region of monomeric immunoglobulin G. FCGRT is present in the intestinal epithelium of neonates and mediates the selective uptake of immunoglobulin G (IgG) in mothers' milk, thereby helping newborn to acquire passive immunity. FCGRT is comprised of a heavy chain and -2-Microglobulin. FCGRT localizes in endosomes of vascular endothelial cells and selectively recycles IgG to the cell surface, thus protecting IgG from lysosomal degradation. |
Immunogen | Immunogen: Recombinant fragment of human FCGRT protein (around aa 24-215) (Exact sequence is proprietary) |
Other Names | [Fc fragment of IgG; receptor transporter; alpha; FCGRT; FCRN; alpha chain; IgG Fc fragment receptor transporter alpha chain; IgG Gc receptor; IgG receptor FcRn large subunit p51; Immunoglobulin receptor; intestinal; heavy chain; Neonatal Fc receptor] |
Gene, Accession # | [FCGRT], Gene ID: 2217, NCBI: NP_001129491.1, UniProt: P55899 |
Catalog # | MBS4380899 |
Price | $190, $340, $340 |
Order / More Info | FCGRT/FcRn (IgG Transporter) Antibody from MYBIOSOURCE INC. |
Product Specific References | Kristi Baker et. al. Neonatal Fc Receptor Expression in Dendritic Cells Mediates Protective Immunity against Colorectal Cancer. Immunity 39 (6); 2013; 1095-1107. |