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Antigenic Specificity | SETD8 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | immunogen affinity purified |
Size | 0.1 mL |
Concentration | 1.0 mg/ml |
Applications | Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | The antibody detects endogenous level of total SETD8 antibody. Protein-lysine N-methyltransferase that monomethylates both histones and non-histone proteins. Specifically monomethylates 'Lys-20' of histone H4 (H4K20me1). H4K20me1 is enriched during mitosis and represents a specific tag for epigenetic transcriptional repression. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. Required for cell proliferation, probably by contributing to the maintenance of proper higher-order structure of DNA during mitosis. Involved in chromosome condensation and proper cytokinesis. Nucleosomes are preferred as substrate compared to free histones. Mediates monomethylation of p53/TP53 at 'Lys-382', |
Immunogen | Immunogen Type: Recombinant Protein Immunogen Description: Recombinant protein of human SETD8. |
Other Names | [SET8; KMT5A; SET07; PR-Set7] |
Gene, Accession # | [SETD8], Gene ID: 387893, NCBI: NP_065115.3, UniProt: Q9NQR1 |
Catalog # | MBS9413540 |
Price | $255 |
Order / More Info | SETD8 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |