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Antigenic Specificity | eIF2alpha (Phospho Ser51) |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | immunogen affinity purified |
Size | 0.1 mL |
Concentration | 1 mg/ml |
Applications | Western Blot (WB), Immunofluorescence (IF), Immunohistochemistry (IHC) Paraffin, ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Specificity: Phospho-eIF2alpha (S51) Polyclonal Antibody detects endogenous levels of eIF2alpha protein only when phosphorylated at S51. The translation initiation factor EIF2 catalyzes the first regulated step of protein synthesis initiation, promoting the binding of the initiator tRNA to 40S ribosomal subunits. Binding occurs as a ternary complex of methionyl-tRNA, EIF2, and GTP. EIF2 is composed of 3 nonidentical subunits, the 36-kD EIF2-alpha subunit (EIF2S1), the 38-kD EIF2-beta subunit (EIF2S2; MIM 603908), and the 52-kD EIF2-gamma subunit (EIF2S3; MIM 300161). The rate of formation of the ternary complex is modulated by the phosphorylation state of EIF2-alpha (Ernst et al., 1987 [PubMed 2948954]). |
Immunogen | Immunogen: Synthesized peptide derived from human eIF2alpha around the phosphorylation site of S51 |
Other Names | [Rabbit eIF2alpha (phospho Ser51); EIF2S1; EIF2A; Eukaryotic translation initiation factor 2 subunit 1; Eukaryotic translation initiation factor 2 subunit alpha; eIF-2-alpha; eIF-2A; eIF-2alpha] |
Gene, Accession # | [eIF2alpha], Gene ID: 1965, NCBI: NP_004085.1, UniProt: P05198 |
Catalog # | MBS9700627 |
Price | $250, $250 |
Order / More Info | eIF2alpha (Phospho Ser51) Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |