Edit |   |
---|---|
Antigenic Specificity | Substance P |
Clone | [NC1/34] |
Host Species | Rat |
Reactive Species | human. predicted: All mammals, Crab, pigeons |
Isotype | IgG2a |
Format | unconjugated |
Size | 0.5 mL |
Concentration | n/a |
Applications | Immunohistochemistry (IHC), Immunocytochemistry (ICC), ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | This antibody recognizes the COOH-terminal end of substance P. It does not recognize Leu-or Met enkephalin, somatostatin or beta-endorphin; crossreactivity with eledoisin: 5%. It recognizes Substance P in post-mortem tissue of the human brain. The discovery of substance P (SP) was reported in 1931. After more than 70 years of investigation, SP is perhaps the best understood neuropeptide transmitter. Substance P is an undecapeptide, which by the mid-1980s was recognized to belong to the tachykinin peptide family; it is also member of the neurokinins. It has been proposed that SP, released from primary afferent nerve endings, plays a role in chronic inflammation and pain. Neurotransmitters appear to play a key role in the regulation of emotio |
Immunogen | Immunogen: Substance P |
Other Names | n/a |
Gene, Accession # | NCBI: ACN37865.1 |
Catalog # | MBS588186 |
Price | $435 |
Order / More Info | Substance P Antibody from MYBIOSOURCE INC. |
Product Specific References | 1. Cuello AC-Detection of substance P in the central nervous system by a monoclonal antibody. 2. Cuello AC-Organization of substance P primary sensory neurons: ultrastructural and physiological correlates. 3. Ramien M-Parasympathetic nerve fibers invade the upper dermis following sensory denervation of the rat lower lip skin. 4. Ruocco I-Skin blood vessels are simultaneously innervated by sensory, sympathetic, and parasympathetic fibers. |