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Antigenic Specificity | Grik4 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | peptide affinity purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Grik4 codes for the KA1 subunit of kainate-type ionotropic glutamate receptors which are critical regulators of network activity that act by modifying neuronal excitability, directly and indirectly, through GABAergic interneurons. Five subunits can assemble to form kainate receptors (KARs): GluR5 (coded by Grik1), GluR6 (coded by Grik2), and GluR7 (coded by Grik3) are the low-affinity subunits, and KA1 and KA2 are the high-affinity subunits. In the adult brain, KARs are located pre- and postsynaptically on pyramidal cells and on interneurons. Kainate receptors on GABA-containing interneurons enhance GABA release and thereby downregulate glutamatergic signaling. KARs have been implicated in numerous psychiatric disorders. Case control studie |
Immunogen | Immunogen Type: Peptide Immunogen Description: Raised against a 14 amino acid peptide near the amino terminus of the human Grik4. |
Other Names | [Glutamate receptor ionotropic kainate 4 precursor, Glutamate receptor KA-1, Excitatory amino acid receptor 1, EEA1] |
Gene, Accession # | [Grik4], Gene ID: 2900, NCBI: NP_001269399.1, UniProt: Q16099 |
Catalog # | MBS9412729 |
Price | $320 |
Order / More Info | Grik4 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |