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Antigenic Specificity | Human Endoglin |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | affinity purified |
Size | 0.1 mL, 0.2 mL |
Concentration | 1mg/ml |
Applications | Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Endoglin (ENG, CD105) is an auxiliary receptor for the TGF-beta receptor complex, functioning in related signaling pathways (1,2). Endoglin is a transmembrane protein that exists as a disulfide-linked homodimer. It is mainly expressed in vascular and connective tissues and in endothelial and stromal cells. Upregulated endoglin expression has been reported during wound healing and tumor vascularization, and in inflammatory tissues and developing embryos (1-4). Mutations in endoglin have been found to be a causal factor of hereditary hemorrhagic telangiectasia (HHT), a disease characterized by malformation of vascular structure (5,6). The importance of this protein for normal and tumor vascular function makes it a good marker for endothelial |
Immunogen | Immunogen: A fusion protein of human Endoglin |
Other Names | [Endoglin Rabbit pab], [ENG; CD105; END; FLJ41744; HHT1; ORW; ORW1] |
Gene, Accession # | Gene ID: 2022, NCBI: NP_000109.1, UniProt: P17813 |
Catalog # | MBS125940 |
Price | $275, $430 |
Order / More Info | Human Endoglin Antibody from MYBIOSOURCE INC. |
Product Specific References | 1. Bernabeu, C. et al. (2007) J Cell Biochem 102, 1375-88. 2. Zhu, Y. et al. (2003) Stroke 34, 2483-8. 3. Quintanilla, M. et al. (2003) Oncogene 22, 5976-85. 4. Dallas, N.A. et al. (2008) Clin Cancer Res 14, 1931-7. 5. ten Dijke, P. et al. (2008) Angiogenesis 11, 79-89. |