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Antigenic Specificity | Mouse GITR |
Clone | [YGIR765.4.16] |
Host Species | Rat |
Reactive Species | mouse |
Isotype | IgG2b |
Format | unconjugated |
Size | 0.25 mg |
Concentration | Antibody concentration: 1.0 mg/ml |
Applications | Functional Assay (FA), In-Vivo Depletion (IV), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Specificity: GITR (Mouse GITR). GITR antibody (clone YGITR 765.4.16) detects mouse GITR (also called TNFRSF18), a 228 aa cysteine-rich protein with a molecular weight of approximately 25 kDa. GITR is a type I transmembrane protein belonging to the tumor necrosis factor/nerve growth factor receptor (TNF/NGFR) family. The mouse GITR gene was localized to murine chromosome 4 (E region) where other TNF/NGFR members localize, including mouse 4- 1BB and OX40. Mouse GITR is expressed at low levels on unstimulated T cells, B cells and macrophages, and increases upon stimulation. GITR promotes the activation, survival and cytokine production of T cells, and can induce the activation of NF-kB and three subfamilies of MAP kinases; ERKs, JNK's and p38. |
Immunogen | Immunogen: Mouse GITR transfectant. Donor: DA rat spleen. Fusion Partner: Y3/Ag 1.2.3 |
Other Names | n/a |
Gene, Accession # | [GITR], NCBI: ACT80311.1 |
Catalog # | MBS520311 |
Price | $350 |
Order / More Info | Mouse GITR Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |