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Antigenic Specificity | NGFR |
Clone | polyclonal |
Host Species | n/a |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | immunogen affinity purified |
Size | 0.1 mg |
Concentration | n/a |
Applications | Western Blot (WB), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Specificity: NGFR Antibody detects endogenous levels of total NGFR. The p75 neurotrophin receptor (p75NTR), a member of the TNF receptor superfamily, is distinguished by multiple cysteine-rich ligand-binding domains, a single transmembrane sequence and a noncatalytic cytoplasmic domain (1). p75NTR displays paradoxical functions when acting alone or with other receptor proteins. Working in concert with Trk receptors, p75NTR recognizes neurotrophins and transmits trophic signals into the cell. Both p75NTR and TrkA are required to activate PI3K-Akt signaling, while TrkA can individually activate the MAP kinase pathway. In contrast, p75NTR, possibly through JNK, ensures appropriate apoptosis of injured neurons and improperly targeted neonatal n |
Immunogen | Immunogen: A synthetic peptide of human NGFR |
Other Names | [CD271; Gp80-LNGFR; TNFRSF16; p75(NTR); p75NTR] |
Gene, Accession # | [NGFR], Gene ID: 4804, NCBI: NP_002498.1, UniProt: P08138 |
Catalog # | MBS8516291 |
Price | $290 |
Order / More Info | NGFR Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |