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Antigenic Specificity | NAK |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | unconjugated |
Size | 0.1 mg |
Concentration | 0.52-0.57 ug/ul in antibody stabilization buffer |
Applications | ELISA (EIA), Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Affinity Purified Serine/Threonine-protein kinase TBK1 Antibody. Serine/threonine kinase that plays an essential role in regulating inflammatory responses to foreign agents. Following activation of toll-like receptors by viral or bacterial components, associates with TRAF3 and TANK and phosphorylates interferon regulatory factors (IRFs) IRF3 and IRF7 as well as DDX3X. This activity allows subsequent homodimerization and nuclear translocation of the IRFs leading to transcriptional activation of pro-inflammatory and antiviral genes including IFNA and IFNB. In order to establish such an antiviral state, TBK1 form several different complexes whose composition depends on the type of cell and cellular stimuli. Thus, several scaffolding molecules |
Immunogen | Immunogen: Synthetic peptide taken within second intracecllular loop of human TBK1 protein. Expression: Ubiquitous with higher expression in testis. Expressed in the ganglion cells, nerve fiber layer and microvasculature of the retina. |
Other Names | [NAK; NF kappa B activating kinase; Serine/threonine protein kinase TBK 1; T2K; TANK; TANK binding kinase 1; TBK 1; TRAF2; TRIF], [TBK1; TBK1; NAK; T2K; FTDALS4; NAK] |
Gene, Accession # | [NAK], Gene ID: 29110, NCBI: NP_037386, UniProt: Q9UHD2 |
Catalog # | MBS540685 |
Price | $390 |
Order / More Info | NAK Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |