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Antigenic Specificity | HOMER1 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | peptide affinity purified |
Size | 0.1 mL, 0.2 mL |
Concentration | 1mg/ml |
Applications | Western Blot (WB), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Specificity: HOMER1 antibody detects endogenous levels of HOMER1. Function: Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. May also couple GRM1 to PI3 kinase through its interaction with AGAP2. Isoform 1 regulates the trafficking and surface expression of GRM5. Isoform 3 acts as a natural dominant negative, in dynamic competition with constitutively expressed isoform 1 to regulate synaptic metabotropic glutamate function. Isoform 3, may be involved in the structural changes that occur at synapses duri |
Immunogen | Immunogen: A synthesized peptide derived from human HOMER1. Subcellular Location: Cytoplasmic; Cell junction, Synapse, Postsynaptic Cell Membrane, Postsynaptic Density. Note=Postsynaptic density of neuronal cells. Isoform 1 inhibits surface expression of GRM5 causing it to be retained in the endoplasmic reticulum. Predicted Cross Reactivity: Pig, Bovine, Horse, Sheep, Rabbit, Dog, Chicken, Xenopus Similarity: Pig (100%), Bovine (100%), Horse (100%), Sheep (100%), Rabbit (100%), Dog (100%), Chick |
Other Names | [HOME1_HUMAN; Homer; HOMER 1A; HOMER 1B; HOMER 1C; Homer homolog 1 (Drosophila); homer homolog 1; Homer protein homolog 1; homer scaffolding protein 1; Homer, Drosophila, homolog of, 1; Homer, neuronal immediate early gene, 1; Homer-1; Homer1; HOMER1A; HOMER1B; HOMER1C; SYN47; Ves 1] |
Gene, Accession # | [HOMER1], Gene ID: 9456, NCBI: NP_001264006.1, UniProt: Q86YM7 |
Catalog # | MBS9603508 |
Price | $240, $280 |
Order / More Info | HOMER1 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |