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Antigenic Specificity | Human Lyve-1 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | Protein A purified |
Size | 0.05 mg |
Concentration | n/a |
Applications | Western Blot (WB), Flow Cytometry (FC/FACS) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | LYVE-1 has been identified as a major receptor for HA (extracellular matrix glycosaminoglycan hyaluronan) on the lymph vessel wall. The deduced amino acid sequence of LYVE-1 predicts a 322-residue type I integral membrane polypeptide 41% similar to the CD44 HA receptor with a 212-residue extracellular domain containing a single Link module the prototypic HA binding domain of the Link protein superfamily. Like CD44, the LYVE-1 molecule binds both soluble and immobilized HA. However, unlike CD44, the LYVE-1 molecule co-localizes with HA on the luminal face of the lymph vessel wall and is completely absent from blood vessels. Hence, LYVE-1 is the first lymph-specific HA receptor to be characterized and is a uniquely powerful marker for lymph v |
Immunogen | Immunogen: Recombinant human KDR (D1-7). Conjugation: Biotin. Preparation: Produced from sera of rabbits pre-immunized with highly pure (> 95%) recombinant human LYVE-1 (Ser24-Gly232) from insect cells. |
Other Names | [human LYVE-1-Biotin; Lymphatic vessel endothelial hyaluronic acid receptor1], [LYVE1; LYVE1; HAR; XLKD1; LYVE-1; CRSBP-1; CRSBP1; HAR; XLKD1; LYVE-1; CRSBP-1] |
Gene, Accession # | [Lyve-1], Gene ID: 10894, NCBI: NP_006682.2, UniProt: Q9Y5Y7 |
Catalog # | MBS691323 |
Price | $330 |
Order / More Info | Human Lyve-1 Antibody from MYBIOSOURCE INC. |
Product Specific References | 1. Carriera et al., Cancer Res 61:8079, 2001 2. Jackson DG Trends Cardiovasc Med 13:1, 2003 3. Sleeman et al., Microsc Res Tech 55:61, 2001 4. Makinen et al., EMBO J 20 : 4762, 2001 |