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Antigenic Specificity | alpha-Synuclein |
Clone | [Syn 211] |
Host Species | Mouse |
Reactive Species | human. |
Isotype | IgG1 |
Format | Protein A purified |
Size | 0.1 mg |
Concentration | n/a |
Applications | ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | This antibody recognizes the 19 kDa protein, -synuclein, which belongs to a family of small cytoplasmic proteins expressed predominantly in neurons. The epitope maps to amino acid residues 121-125 of human -synuclein. -synuclein may be involved in neuronal plasticity and could act as a molecular chaperone that mediates the transformation of soluble A into insoluble amyloid. The protein is a major component of Lewy bodies, the pathological hallmark of Parkinson?s disease, and is also observed in senile plaques of Alzheimer?s disease patients. Human -synuclein appears to be phosphorylated at two major sites, serine 129 and serine 87, and phosphorylation may play a role in the functional regulation of the protein. |
Immunogen | Immunogen: Recombinant human alpha-synuclein. |
Other Names | [Non-A beta component of AD amyloid; Non-A4 component of amyloid precursor; NACP], [SNCA; SNCA; PD1; NACP; PARK1; PARK4; NACP; PARK1; NACP] |
Gene, Accession # | [alpha-Synuclein], Gene ID: 6622, NCBI: NP_000336.1, UniProt: P37840 |
Catalog # | MBS395263 |
Price | $615 |
Order / More Info | alpha-Synuclein Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |