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Antigenic Specificity | Phospho-IRF3 (S386) |
Clone | monoclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | affinity purified |
Size | 0.03 mg, 0.1 mg, 0.1 mg |
Concentration | n/a |
Applications | Immunofluorescence (IF), Immunocytochemistry (ICC), Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Key transcriptional regulator of type I interferon (IFN)-dependent immune responses which plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. Acts as a more potent activator of the IFN-beta (IFNB) gene than the IFN-alpha (IFNA) gene and plays a critical role in both the early and late phases of the IFNA/B gene induction. Found in an inactive form in the cytoplasm of uninfected cells and following viral infection, double-stranded RNA (dsRNA), or toll-like receptor (TLR) signaling, is phosphorylated by IKBKE and TBK1 kinases. This |
Immunogen | Immunogen: A synthesized peptide derived from human Phospho-IRF3 (S386) Subcellular Localization: Cytoplasm. Nucleus. Shuttles between cytoplasmic and nuclear compartments, with export being the prevailing effect. When activated, IRF3 interaction with CREBBP prevents its export to the cytoplasm. Tissue Specificity: Expressed constitutively in a variety of tissues. |
Other Names | [Interferon regulatory factor 3; IRF-3; IRF3] |
Gene, Accession # | [IRF3], Gene ID: 3661, NCBI: NP_001184051.1, UniProt: Q14653 |
Catalog # | MBS1750216 |
Price | $160, $340, $340 |
Order / More Info | Phospho-IRF3 (S386) Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |