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Antigenic Specificity | ADAMTS4 (Aggrecanase I, A Disintegrin And Metalloproteinase with Thrombospondin motifs 4) |
Clone | polyclonal |
Host Species | Goat |
Reactive Species | human |
Isotype | n/a |
Format | immunoaffinity purified |
Size | 0.1 mg |
Concentration | n/a |
Applications | ELISA (EL/EIA), Western Blot (WB), Immunoprecipitation (IP) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Recognizes human ADAMTS4. Shows ~10% crossreactivity with recombinant human ADAMTS5 and <1% crossreactivity with recombinant human ADAMTS13, ADAMTSL1.2 and ADAMTS1 in Western Blot and ELISA. ADAMTS4 is a member of the family of secreted zinc proteases with a multi-domain structure (1-3). The protein precursors consist of a signal peptide and the following domains: pro, catalytic, disintegrin-like, TS type 1 motif, cysteine-rich and spacer. It is the only ADAMTS identified that has one TS type I motif. It is an active protease effectively cleaving alpha-2-macroglobulin and aggrecan at multiple sites, and is inhibited by TIMP-3 with inhibition constants in subnanomolar range (4-6). It receives great attention due to the elevation in its |
Immunogen | Immunogen: Recombinant corresponding to Phe213-Cys685 from human ADAMTS4 expressedin CHO cells (O75173). |
Other Names | [-ADAMTS4 (Aggrecanase I, A Disintegrin And Metalloproteinase with Thrombospondin motifs 4)], [ADAMTS4; ADAMTS4; ADMP-1; ADAMTS-2; ADAMTS-4; KIAA0688; KIAA0688] |
Gene, Accession # | Gene ID: 9507, NCBI: NP_005090.3, UniProt: O75173 |
Catalog # | MBS620136 |
Price | $765 |
Order / More Info | ADAMTS4 (Aggrecanase I, A Disintegrin And Metalloproteinase with Thrombospondin motifs 4) Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |