APRT Antibody from MYBIOSOURCE INC.
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|---|---|
| Antigenic Specificity | APRT |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, mouse, rat |
| Isotype | n/a |
| Format | immunogen affinity purified |
| Size | 0.1 mg |
| Concentration | n/a |
| Applications | Western Blot (WB), Immunohistochemistry (IHC) Paraffin |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Specificity: No cross reactivity with other proteins. Description: Rabbit IgG polyclonal antibody for APRT detection. Tested with WB, IHC-P in Human; Mouse; Rat.Background: Adenine phosphoribosyltransferase (APRTase) is an enzyme encoded by the APRT gene, found in humans on chromosome 16. It belongs to the purine/pyrimidine phosphoribosyltransferase family. A conserved feature of this gene is the distribution of CpG dinucleotides. This enzyme catalyzes the formation of AMP and inorganic pyrophosphate from adenine and 5-phosphoribosyl-1-pyrophosphate (PRPP). It also produces adenine as a by-product of the polyamine biosynthesis pathway. A homozygous deficiency in this enzyme causes 2, 8-dihydroxyadenine urolithiasis. Two transcript varia |
| Immunogen | Immunogen: A synthetic peptide corresponding to a sequence of mouse APRT (RAEVVECVSLVELTSLKGRERL). |
| Other Names | [Adenine phosphoribosyltransferase; APRT; Aprt] |
| Gene, Accession # | [APRT], Gene ID: 11821, NCBI: NP_033828.2, UniProt: P08030 |
| Catalog # | MBS1751435 |
| Price | $315 |
| Order / More Info | APRT Antibody from MYBIOSOURCE INC. |
| Product Specific References | 1. Silva CH, Silva M, Iulek J, Thiemann OH (Jun 2008). Structural complexes of human adenine phosphoribosyltransferase reveal novel features of the APRT catalytic mechanism. Journal of Biomolecular Structure & Dynamics. 25 (6): 589-97. 2. Sarver AE, Wang CC (Oct 2002). The adenine phosphoribosyltransferase from Giardia lamblia has a unique reaction mechanism and unusual substrate binding properties. The Journal of Biological Chemistry. 277 (42): 39973-80. 3. Valaperta R, Rizzo V, Lombardi F, Verdelli C, Piccoli M, Ghiroldi A, Creo P, Colombo A, Valisi M, Margiotta E, Panella R, Costa E (1 July 2014). Adenine phosphoribosyltransferase (APRT) deficiency: identification of a novel nonsense mutation. BMC Nephrology. 15: 102. |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
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