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Antigenic Specificity | VGLUT1 |
Clone | [S28-9] |
Host Species | Mouse |
Reactive Species | human, mouse, rat |
Isotype | IgG1 |
Format | APC-Cy7 conjugate |
Size | 0.1 mg |
Concentration | 1 mg/ml |
Applications | Western Blot (WB), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Detects ~52 kDa. No cross-reactivity against VGlut2. VGLUT1 is expressed in a subset of glutamate neurons and transports glutamate into native synaptic vesicles from the brain, exhibiting a conductance for chloride that is blocked by glutamate (1). Vesicular glutamate transport has a substantially lower apparent affinity than the plasma membrane excitatory amino acid transporters. Glutamate transport by VGLUT1 is saturated with a K(m) of approximately 2 mM, in the same range as transport by synaptic vesicles. Finally, plasma membrane glutamate transporters recognize both aspartate and glutamate as substrates, whereas VGLUT1 does not recognize aspartate (2). |
Immunogen | Immunogen: Fusion protein amino acids 493-560 (cytoplasmic C-terminus) of rat VGlut1 |
Other Names | [Mouse Rat VGLUT1 IgG1; VGLUT1 : APC/Cy7; BNPI; SLC17A1; SLC17A1/VGLUT1; Solute Carrier family 17 member 7; Vesicular glutamate transporter 1; VGLUT 1; Brain-specific Na(+)-dependent inorganic phosphate cotransporter] |
Gene, Accession # | [VGLUT1], Gene ID: 116638, NCBI: NP_446311.1, UniProt: Q62634 |
Catalog # | MBS8003058 |
Price | $510 |
Order / More Info | VGLUT1 Antibody from MYBIOSOURCE INC. |
Product Specific References | 1. Wojcik S.M., et al. (2004) PNAS. 101(18): 7158-7163. 2. Shigeri Y., Seal R.P., Shimamoto K. (2004) Brain Res Rev. 45(3): 250-265. |