NIPA Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | NIPA |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human |
| Isotype | n/a |
| Format | peptide affinity purified |
| Size | 0.1 mL, 0.2 mL |
| Concentration | 1mg/ml |
| Applications | Western Blot (WB), Immunofluorescence (IF), Immunocytochemistry (ICC), ELISA (EIA) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Specificity: NIPA antibody detects endogenous levels of total NIPA. Function: Essential component of a SCF-type E3 ligase complex, SCF(NIPA), a complex that controls mitotic entry by mediating ubiquitination and subsequent degradation of cyclin B1 (CCNB1). Its cell-cycle-dependent phosphorylation regulates the assembly of the SCF(NIPA) complex, restricting CCNB1 ubiquitination activity to interphase. Its inactivation results in nuclear accumulation of CCNB1 in interphase and premature mitotic entry. May have an antiapoptotic role in NPM-ALK-mediated signaling events.Subunit Structure: Interacts with the NPM-ALK fusion protein in a tyrosine phosphorylation-dependent manner. Interacts with SKP1. Component of a SCF(NIPA) E3 complex with SK |
| Immunogen | Immunogen: A synthesized peptide derived from human NIPA Subcellular Location: Nucleus. Tissue Specificity: Widely expressed. Highly expressed in heart, skeletal muscle and testis. Expressed in brain, placenta, lung, kidney, liver, pancreas, spleen, thymus, prostate, ovary small intestine and colon. Weakly or not expressed in leukocytes. Predicted Cross Reactivity: Pig, Bovine, Horse, Sheep, Rabbit, Dog Similarity: Pig (100%), Bovine (91%), Horse (91%), Sheep (91%), Rabbit (90%), Dog (100%) |
| Other Names | [hNIPA; NIPA_HUMAN; Nuclear interacting partner of ALK; Nuclear interacting partner of anaplastic lymphoma kinase; Nuclear-interacting partner of ALK; Nuclear-interacting partner of anaplastic lymphoma kinase; zc3hc1; Zinc finger C3HC type containing 1; Zinc finger C3HC-type protein 1] |
| Gene, Accession # | [NIPA], Gene ID: 51530, NCBI: NP_001269119.1, UniProt: Q86WB0 |
| Catalog # | MBS9602175 |
| Price | $240, $280 |
| Order / More Info | NIPA Antibody from MYBIOSOURCE INC. |
| Product Specific References | n/a |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
sales@mybiosource.com
http://www.MyBioSource.com
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