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Antigenic Specificity | BACE2 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | peptide affinity purified |
Size | 0.1 mg |
Concentration | n/a |
Applications | ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | BACE2 Antibody: Accumulation of the amyloid-beta (Abeta) plaque in the cerebral cortex is a critical event in the pathogenesis of Alzheimer's disease. Abeta peptide is generated by proteolytic cleavage of the beta-amyloid protein precursor (APP) at beta- and gamma-sites by proteases. The long-sought beta-secretase was recently identified by several groups independently and designated beta-site APP cleaving enzyme (BACE) and aspartyl protease 2 (Asp2). BACE/Asp2 is a novel transmembrane aspartic protease and co-localizes with APP. A BACE homolog was recently cloned and designated BACE2, Asp1, DRAP (for Down region aspartic protease), and memapsin 1. BACE2 also cleaves APP at b-site and at a different site within Abeta. BACE2 locates on chrom |
Immunogen | Immunogen: BACE2 antibody was raised against a peptide corresponding to amino acids near the carboxy terminus of human BACE2. Buffer: BACE2 Antibody is supplied in PBS containing 0.02% sodium azide. |
Other Names | [BACE2; ASP1; BAE2; DRAP; AEPLC; ALP56; ASP21; CDA13; CEAP1; UNQ418/PRO852; Beta-secretase 2; Aspartic-like protease 56 kDa; ASP1; beta-site APP-cleaving enzyme 2], [BACE2; BACE2; ASP1; BAE2; DRAP; AEPLC; ALP56; ASP21; CDA13; CEAP1; AEPLC; ALP56; ASP21; ASP1; Asp 1; Beta-site APP cleaving enzyme 2; DRAP] |
Gene, Accession # | [BACE2], Gene ID: 25825, NCBI: AAF17078, UniProt: Q9Y5Z0 |
Catalog # | MBS150389 |
Price | $375 |
Order / More Info | BACE2 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |