Cyclin D1 (G1-Cyclin & Mantle Cell Marker) Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | Cyclin D1 (G1-Cyclin & Mantle Cell Marker) |
| Clone | [CCND1/809] |
| Host Species | Mouse |
| Reactive Species | human |
| Isotype | IgG2a, kappa |
| Format | phycoerythrin (PE) conjugate |
| Size | 0.5 mL |
| Concentration | n/a |
| Applications | Flow Cytometry (FC/FACS), Immunofluorescence (IF) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Recognizes a protein of 36kDa, identified as cyclin D1. Cyclin D1, one of the key cell cycle regulators, is a putative proto-oncogene overexpressed in a wide variety of human neoplasms. This antibody neutralizes the activity of cyclin D1 in vivo. About 60% of mantle cell lymphomas (MCL) contain a t(11; 14)(q13; q32) translocation resulting in over-expression of cyclin D1. This antibody is useful in identifying mantle cell lymphomas (cyclin D1 positive) from CLL/SLL and follicular lymphomas (cyclin D1 negative). Occasionally, hairy cell leukemia and plasma cell myeloma weakly express Cyclin D1. |
| Immunogen | Immunogen: Recombinant full-length human CCND1 protein |
| Other Names | [B cell CLL/lymphoma 1, B cell leukemia 1, B-cell lymphoma 1 protein, BCL-1 oncogene, CCND1 protein, CCND1/FSTL3 fusion gene, CCND1/IGHG1 fusion gene CCND1/IGLC1 fusion gene, CCND1/PTH fusion gene, cD1, Cyl 1, G1/S-specific cyclin-D1, Parathyroid adenomatosis 1, PRAD1 oncogene], [CCND1; CCND1; BCL1; PRAD1; U21B31; D11S287E; BCL1; PRAD1; BCL-1] |
| Gene, Accession # | [CCND1], Gene ID: 595, NCBI: NP_444284.1, UniProt: P24385 |
| Catalog # | MBS439279 |
| Price | $340 |
| Order / More Info | Cyclin D1 (G1-Cyclin & Mantle Cell Marker) Antibody from MYBIOSOURCE INC. |
| Product Specific References | Baldin V; Lukas J; Marcote MJ; Pagano M; Draetta G. Cyclin D1 is a nuclear protein required for cell cycle progression in G1. Genes and Development, 1993, 7(5):812-21. |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
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San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
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