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Antigenic Specificity | GABA-B Receptor 1 |
Clone | [S93A-49] |
Host Species | Mouse |
Reactive Species | human, mouse, rat |
Isotype | IgG1 |
Format | allophycocyanin (APC) conjugate |
Size | 0.1 mg |
Concentration | 1mg/mL |
Applications | Western Blot (WB), Immunocytochemistry (ICC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Background Info: Detects ~115kDa. No cross-reactivity against GABA(Beta)R2. Scientific Background: GABA (gamma-aminobutyric acid) is the primary inhibitory neurotransmitter in the central nervous system and interacts with three different receptors: GABA(A), GABA(B) and GABA(C) receptor. The ionotropic GABA(A) and GABA(C) receptors are ligand-gated ion channels that produce fast inhibitory synaptic transmission. In contrast, the metabotropic GABA(B) receptor is coupled to G proteins that modulate slow inhibitory synaptic transmission (1). Functional GABA(B) receptors form heterodimers of GABA(B)R1 and GABA(B)R2 where GABA(B)R1 binds the ligand and GABA(B)R2 is the primary G protein contact site (2). Two isoforms of GABA(B)R1 have been cloned |
Immunogen | n/a |
Other Names | [GABA-B receptor 1; GABA-B-R1; GABR1_Human; Gamma aminobutyric acid receptor 1; GB1; GPRC3A], [Gabbr1; Gabbr1; GABA-B receptor 1; GABA-B-R1; GABA-BR1; GABABR1; Gb1] |
Gene, Accession # | Gene ID: 81657, NCBI: NP_112290.2, UniProt: Q9Z0U4 |
Catalog # | MBS800327 |
Price | $435 |
Order / More Info | GABA-B Receptor 1 Antibody from MYBIOSOURCE INC. |
Product Specific References | 1. Jones K.A. et al. (2000) Neuropsychopharmacology 23: 2. Duthey B. et al. (2002) J Biol Chem. 277: 3236-41. 3. Kaupmann K. et al. (1997) Nature 386: 239-46. |