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Antigenic Specificity | Phospho-Sin1 (Ser510) |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mousepredicted: porcine, bovine, horse, sheep, rabbit, dog, chicken, Xenopus |
Isotype | n/a |
Format | peptide affinity purified |
Size | 0.05 mL, 0.1 mL, 0.2 mL |
Concentration | 1mg/ml |
Applications | Western Blot (WB), Peptide ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Specificity: Phospho-Sin1 (Ser510) Antibody detects endogenous levels of Sin1 only when phosphorylated at Ser510. Description: Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full |
Immunogen | Immunogen: A synthesized peptide derived from human Sin1 around the phosphorylation site of Ser510. Tissue Specificity: Ubiquitously expressed, with highest levels in heart and skeletal muscle. |
Other Names | [MAPKAP 1; MAPKAP1; MEKK2 interacting protein 1; MGC2745; MIP 1; MIP1; Mitogen activated protein kinase associated protein 1; Mitogen-activated protein kinase 2-associated protein 1; mSIN1; OTTHUMP00000064207; Ras inhibitor MGC2745; SAPK interacting protein 1; SAPK-interacting protein 1; SIN 1; SIN1_HUMAN; SIN1b; SIN1g; Stress activated map kinase interacting protein 1; Stress activated protein kinase interacting 1; Stress-activated map kinase-interacting protein 1; Target of rapamycin complex 2 subunit MAPKAP1; TORC2 subunit MAPKAP1] |
Gene, Accession # | [Sin1], Gene ID: 79109, NCBI: Q9BPZ7.2, UniProt: Q9BPZ7 |
Catalog # | MBS9610798 |
Price | $225, $280, $340 |
Order / More Info | Phospho-Sin1 (Ser510) Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |