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Antigenic Specificity | MARCH1 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | peptide affinity purified |
Size | 0.1 mL, 0.2 mL |
Concentration | 1mg/ml |
Applications | Western Blot (WB), ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Specificity: MARCH1 antibody detects endogenous levels of total 42430. Function: E3 ubiquitin-protein ligase that mediates ubiquitination of TFRC, CD86, FAS and MHC class II proteins, such as HLA-DR alpha and beta, and promotes their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. By constitutively ubiquitinating MHC class II proteins in immature dendritic cells, down-regulates their cell surface localization thus sequestering them in the intracellular endosomal system.Post-translational Modifications: Has a short half-life. Instability/short half-life permits rapid changes that allow efficient induction of antigen presentation once antigen presenting cells, APCs, receive maturation signals. Small changes in p |
Immunogen | Immunogen: A synthesized peptide derived from human MARCH1 Subcellular Location: Lysosome; Endosome; Golgi Apparatus; Plasma Membrane Tissue Specificity: Expressed in antigen presenting cells, APCs, located in lymph nodes and spleen. Also expressed in lung. Expression is high in follicular B-cells, moderate in dendritic cells and low in splenic T-cells. Predicted Cross Reactivity: Rabbit, Chicken Similarity: Rabbit (100%), Chicken (86%) |
Other Names | [DKFZp564M1682; E3 ubiquitin protein ligase MARCH1; E3 ubiquitin-protein ligase MARCH1; FLJ20668; MARCH 1; MARCH-I; March1; MARH1_HUMAN; Membrane associated RING CH protein I; Membrane associated ring finger (C3HC4) 1; Membrane associated ring finger (C3HC4) 1, E3 ubiquitin protein ligase; Membrane associated RING finger protein 1; Membrane-associated RING finger protein 1; Membrane-associated RING-CH protein I; RING finger protein 171; RNF171] |
Gene, Accession # | [MARCH1], Gene ID: 55016, NCBI: NP_001159845.1, UniProt: Q8TCQ1 |
Catalog # | MBS9609798 |
Price | $240, $280 |
Order / More Info | MARCH1 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |