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Antigenic Specificity | Phospho-Ack1 (Tyr857/858) |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | peptide affinity purified |
Size | 0.1 mL, 0.2 mL |
Concentration | 1mg/ml |
Applications | Western Blot (WB), Immunofluorescence (IF), Immunocytochemistry (ICC), ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Specificity: Phospho-Ack1 (Tyr857/858) antibody detects endogenous levels of Ack1 only when phosphorylated at Tyr857/858. Function: Non-receptor tyrosine-protein and serine/threonine-protein kinase that is implicated in cell spreading and migration, cell survival, cell growth and proliferation. Transduces extracellular signals to cytosolic and nuclear effectors. Phosphorylates AKT1, AR, MCF2, WASL and WWOX. Implicated in trafficking and clathrin-mediated endocytosis through binding to epidermal growth factor receptor (EGFR) and clathrin. Binds to both poly-and mono-ubiquitin and regulates ligand-induced degradation of EGFR, thereby contributing to the accumulation of EGFR at the limiting membrane of early endosomes. Downstream effector of C |
Immunogen | Immunogen: A synthesized peptide derived from human Phospho-Ack1 (Tyr857/858) Subcellular Location: Cell Membrane. Nucleus. Endosome. Cell Junction > Adherens Junction. Cytoplasmic Vesicle Membrane. The Tyr-284 phosphorylated form is expressed both in the membrane and nucleus. Co-localizes with EGFR on the endosomes. Tissue Specificity: The Tyr-284 phosphorylated form shows a significant increase in expression in breast cancers during the progressive stages i.e. normal to hyperplasia (ADH), duct |
Other Names | [Acetate kinase 1; Acetokinase 1; ACK 1; ACK; ACK-1; ACK1; ACK1_HUMAN; Activated Cdc42 associated kinase 1; Activated CDC42 kinase 1; Activated p21cdc42Hs kinase; FLJ44758; FLJ45547; p21cdc42Hs; TNK 2; TNK2; Tyrosine kinase non receptor 2; Tyrosine kinase non receptor protein 2; Tyrosine kinase non-receptor protein 2] |
Gene, Accession # | [Ack1], Gene ID: 10188, NCBI: NP_001010938.1, UniProt: Q07912 |
Catalog # | MBS9604462 |
Price | $240, $280 |
Order / More Info | Phospho-Ack1 (Tyr857/858) Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |