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Antigenic Specificity | AIB1 |
Clone | [50B6] |
Host Species | Mouse |
Reactive Species | human |
Isotype | n/a |
Format | Protein G purified |
Size | 0.1 mg |
Concentration | n/a |
Applications | Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Recognizes human AIB1. Detects a band of ~160kDa by Western blot. AIB1 is a member of the p160/steroid receptor coactivator (SRC) family, named for its common amplification in breast cancer. Members of this family include a defined nuclear receptor box motif (LxxLL) that is critical for binding to nuclear hormone receptors, and two C-terminal activation domains that bind secondary coactivators such as the p300/CREB binding protein (CBP) and CARM-1 to confer acetyltransferase or methyltransferase downstream signals, respectively. AIB1 binds to estrogen receptor (ER), and its overexpression in hormone-responsive cancers and frequent amplification in breast and other cancers make it a focus for the treatment of cancer and the study of hormone |
Immunogen | Immunogen: Recombinant human AIB1. |
Other Names | [Nuclear receptor coactivator 3; NCoA-3; SRC-3], [NCOA3; NCOA3; ACTR; AIB1; RAC3; SRC3; pCIP; AIB-1; CTG26; SRC-3; CAGH16; KAT13B; TNRC14; TNRC16; TRAM-1; bHLHe42; AIB1; BHLHE42; RAC3; TRAM1; NCoA-3; AIB-1; pCIP; bHLHe42; RAC-3; SRC-3; TRAM-1] |
Gene, Accession # | [AIB1], Gene ID: 8202, NCBI: Q9Y6Q9.1, UniProt: Q9Y6Q9 |
Catalog # | MBS565058 |
Price | $370 |
Order / More Info | AIB1 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |