Gli2 Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | Gli2 |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, mouse, rat |
| Isotype | n/a |
| Format | immunogen affinity purified |
| Size | 0.1 mL, 0.2 mL |
| Concentration | 1.0mg/ml |
| Applications | Western Blot (WB), Immunohistochemistry (IHC) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Specificity: Gli2 Antibody detects endogenous levels of total Gli2. Functions as transcription regulator in the hedgehog (Hh) pathway (PubMed:18455992). Functions as transcriptional activator (PubMed:9557682, PubMed:19878745, PubMed:24311597). May also function as transcriptional repressor (By similarity). Requires STK36 for full transcriptional activator activity. Required for normal embryonic development (PubMed:15994174, PubMed:20685856)./Isoform 1, isoform 2, isoform 3 and isoform 4: Act as transcriptional activators in T-cell leukemia virus type 1 (HTLV-1)-infected cells in a Tax-dependent manner. Bind to the DNA sequence 5'-GAACCACCCA-3' which is part of the Tax-responsive element (TRE-2S) regulatory element that augments the Tax-depe |
| Immunogen | Immunogen: A synthesized peptide derived from human Gli2 Subcellular Location: Nucleus Cytoplasm Cell projection Cilium STK36 promotes translocation to the nucleus. In keratinocytes, it is sequestered in the cytoplasm by SUFU. In the absence of SUFU, it translocates to the nucleus. /Isoform 1 Nucleus /Isoform 2 Nucleus. Post-translational Modifications: Phosphorylated in vitro by ULK3. Phosphorylated by DYRK2; this inhibits GLI2 transcription factor activity and promotes proteasomal degradation |
| Other Names | [CDK5, CRK6, Cell division protein kinase 5, EC 2.7.11.22, PSSALRE, TAU protein kinase II catalytic subunit, TPKII catalytic subunit, Tau protein kinase II catalytic subunit, kinase Cdk5] |
| Gene, Accession # | [Gli2], Gene ID: 2736, NCBI: NP_005261.2, UniProt: P10070 |
| Catalog # | MBS9385005 |
| Price | $440, $715 |
| Order / More Info | Gli2 Antibody from MYBIOSOURCE INC. |
| Product Specific References | n/a |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
sales@mybiosource.com
http://www.MyBioSource.com
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