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Antigenic Specificity | LGR4 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | affinity purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and is involved in the formation of various organs. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal. Its function as activator of the Wnt signaling pathway is required for the development of various organs, including liver, kidney, intestine, bone, reproductive tract and eye. May also act as a receptor for norrin (NDP), such results however |
Immunogen | Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 320-540 of human LGR4 (NP 060960.2). |
Other Names | [leucine-rich repeat-containing G-protein coupled receptor 4 isoform 1; Leucine-rich repeat-containing G-protein coupled receptor 4; leucine-rich repeat-containing G-protein coupled receptor 4; leucine rich repeat containing G protein-coupled receptor 4; G-protein coupled receptor 48] |
Gene, Accession # | [LGR4], Gene ID: 55366, NCBI: NP_060960.2, UniProt: Q9BXB1 |
Catalog # | MBS8548415 |
Price | $280 |
Order / More Info | LGR4 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |