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Antigenic Specificity | Ep-CAM/CD326 (Extracellular Domain) (Epithelial Marker) |
Clone | [Ber-EP4] |
Host Species | Mouse |
Reactive Species | human |
Isotype | IgG1, kappa |
Format | supernatant |
Size | 0.1 mL, 0.5 mL |
Concentration | n/a |
Applications | Immunohistochemistry (IHC) Paraffin |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Recognizes a 40-43kDa transmembrane epithelial glycoprotein, identified as epithelial specific antigen (ESA), or epithelial cellular adhesion molecule (Ep-CAM). It is expressed on baso-lateral cell surface in most simple epithelia and a vast majority of carcinomas with the exception of adult squamous epithelium, hepatocytes and gastric epithelial cells. This antibody has been used to distinguish adenocarcinoma from pleural mesothelioma and hepatocellular carcinoma. It is also useful in distinguishing serous carcinomas of the ovary from mesothelioma. It has been reported that this epithelial antigen plays an important role as a tumor-cell marker in lymph nodes from patients with esophageal carcinoma otherwise classified as node-negative. Epi |
Immunogen | Immunogen: Human breast cancer MCF-7 cells |
Other Names | [Adenocarcinoma-associated Antigen; Cell Surface Glycoprotein Trop-1; EGP2; EGP314; EGP40; Epithelial Cell Adhesion Molecule; Epithelial Glycoprotein 314; ESA; KSA; TACD1; TACSTD1; TROP1; Tumor-associated Calcium Signal Transducer 1] |
Gene, Accession # | [Ep-CAM/CD326], Gene ID: 4072, NCBI: NP_002345.2, UniProt: P16422 |
Catalog # | MBS4381070 |
Price | $190, $340 |
Order / More Info | Ep-CAM/CD326 (Extracellular Domain) (Epithelial Marker) Antibody from MYBIOSOURCE INC. |
Product Specific References | Latza U, Niedobitek G, Schwarting R, Nekarda H, Stein H. Ber-EP4: new monoclonal antibody which distinguishes epithelia from mesothelia. J Clin Pathol 1990;43:213-9. |