Edit |   |
---|---|
Antigenic Specificity | PPM1A |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | immunogen affinity purified |
Size | 0.1 mL |
Concentration | 1.0 mg/ml |
Applications | Western Blot (WB), Immunofluorescence (IF) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | The antibody detects endogenous level of total PPM1A antibody. The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase dephosphorylates, and negatively regulates the activities of, MAP kinases and MAP kinase kinases. It has been shown to inhibit the activation of p38 and JNK kinase cascades induced by environmental stresses. This phosphatase can also dephosphorylate cyclin-dependent kinases, and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to activate the expression of the tumor suppressor gene TP53/p53, which leads to G2/M cell cycle arrest and apop |
Immunogen | Immunogen Type: Recombinant Protein Immunogen Description: Recombinant protein of human PPM1A. |
Other Names | [PP2CA; PP2Calpha; PP2C-ALPHA] |
Gene, Accession # | [PPM1A], Gene ID: 5494, NCBI: NP_066283.1, UniProt: P35813 |
Catalog # | MBS9414118 |
Price | $255 |
Order / More Info | PPM1A Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |