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Antigenic Specificity | CD14 |
Clone | polyclonal |
Host Species | n/a |
Reactive Species | human, mouse |
Isotype | n/a |
Format | affinity purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | This antibody is produced by immunizing rabbits with a synthetic peptide (KLH-coupled) corresponding to a region of CD14. CD14 is a glycophosphatidylinositol-anchored protein expressed on the surfaces of monocytes and plymorphonuclear leukocytes. It cooperates with MD-2 and TLR4 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). CD14 acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response and up-regulates cell surface molecules, including adhesion molecules. |
Immunogen | n/a |
Other Names | [monocyte differentiation antigen CD14; Monocyte differentiation antigen CD14; monocyte differentiation antigen CD14; CD14 molecule; Myeloid cell-specific leucine-rich glycoprotein; CD_antigen: CD14], [CD14; CD14] |
Gene, Accession # | [CD14], Gene ID: 929, NCBI: NP_000582.1, UniProt: P08571 |
Catalog # | MBS859660 |
Price | $280 |
Order / More Info | CD14 Antibody from MYBIOSOURCE INC. |
Product Specific References | 1. Crystal structure of CD14 and its implications for lipopolysaccharide signaling.Kim J.I., Lee C.J., Jin M.S., Lee C.H., Paik S.G., Lee H., Lee J.O.J. Biol. Chem. 280:11347 11351(2005). The phagosomal proteome in interferon-gamma-activated macrophages.Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.Immunity 30:143 154(2009). |