CD3E Antibody from MYBIOSOURCE INC.
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| Edit | |
|---|---|
| Antigenic Specificity | CD3E |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, mouse, rat |
| Isotype | n/a |
| Format | affinity purified |
| Size | 0.1 mL |
| Concentration | n/a |
| Applications | Western Blot (WB), Immunohistochemistry (IHC) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | When T cells encounter antigens via the T cell receptor (TCR), information about the quantity and quality of antigens is relayed to the intracellular signal transduction machinery (1). This activation process depends mainly on CD3 (Cluster of Differentiation 3), a multiunit protein complex that directly associates with the TCR. CD3 is composed of four polypeptides: zeta, gamma, epsilon and delta. Each of these polypeptides contains at least one immunoreceptor tyrosine-based activation motif (ITAM) (2). Engagement of TCR complex with foreign antigens induces tyrosine phosphorylation in the ITAM motifs and phosphorylated ITAMs function as docking sites for signaling molecules such as ZAP-70 and p85 subunit of PI-3 kinase (3, 4). TCR ligation |
| Immunogen | Immunogen: Recombinant protein of human CD3E Storage Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Other Names | [CD3 epsilon; FLJ18683; T3E; TCRE] |
| Gene, Accession # | [CD3E], Gene ID: 916, NCBI: NP_000724.1, UniProt: P07766 |
| Catalog # | MBS8500017 |
| Price | $310 |
| Order / More Info | CD3E Antibody from MYBIOSOURCE INC. |
| Product Specific References | 1. Kuhns, M.S. et al. (2006) Immunity 24, 133-139. 2. Pitcher, L.A. and van Oers, N.S. (2003) Trends Immunol. 24, 554-560. 3. Osman, N. et al. (1996) Eur. J. Immunol. 26, 1063-1068. 4. Hatada, M.H. et al. (1995) Nature 377, 32-38. 5. Gil, D. et al. (2002) Cell 109, 901-912. |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
sales@mybiosource.com
http://www.MyBioSource.com
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