Edit |   |
---|---|
Antigenic Specificity | Tyrosine Kinase Receptor B (TrkB, 23-36) |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, rat |
Isotype | n/a |
Format | unconjugated |
Size | 0.1 mL |
Concentration | 1ug/ul |
Applications | Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Specificity: Sequence was chosen to avoid cross reactivity with TrkA and TrkC. FUNCTION: Receptor for brain-derived neurotrophic factor (BDNF), neurotrophin-3 and neurotrophin-4/5 but not nerve growth factor (NGF). Involved in the development and/or maintenance of the nervous system. This is a tyrosine-protein kinase receptor. Known substrates for the TRK receptors are SHC1, PI-3 kinase, and PLC-gamma-1. CATALYTIC ACTIVITY: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. SUBUNIT: Exists in a dynamic equilibrium between monomeric (low affinity) and dimeric (high affinity) structures (By similarity). Binds APS. Interacts with SQSTM1. SUBCELLULAR LOCATION: Membrane; single-pass type I membrane protein. ALTERNATIVE produc |
Immunogen | Immunogen: A synthetic peptide (AFPRLEPNSIDPENC) as part of rat mature TrkB protein (aa: 23-36) conjugated to KLH. Storage Buffer: PBS, pH 7.4 with 0.02% sodium azide. |
Other Names | [trkB; BDNF/NT-3 growth factors receptor; BDNF/NT-3 growth factors receptor; neurotrophic receptor tyrosine kinase 2; GP145-TrkB; Trk-B; Neurotrophic tyrosine kinase receptor type 2; TrkB tyrosine kinase; Tropomyosin-related kinase B] |
Gene, Accession # | [TrkB], Gene ID: 4915, NCBI: AAB33109.1 |
Catalog # | MBS4152715 |
Price | $515 |
Order / More Info | Tyrosine Kinase Receptor B (TrkB, 23-36) Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |