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Antigenic Specificity | SS18L1 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse |
Isotype | n/a |
Format | Protein G purified |
Size | 0.05 mg, 0.1 mg |
Concentration | n/a |
Applications | ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which lead |
Immunogen | Immunogen: Recombinant human Calcium-responsive transactivator protein |
Other Names | [Calcium-responsive transactivator; SS18-like protein 1; SYT homolog 1; SS18L1; CREST; KIAA0693] |
Gene, Accession # | [SS18L1], Gene ID: 26039, NCBI: NP_001288707.1, UniProt: O75177 |
Catalog # | MBS7044694 |
Price | $160, $235 |
Order / More Info | SS18L1 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |