EWS Antibody from MYBIOSOURCE INC.
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| Edit | |
|---|---|
| Antigenic Specificity | EWS |
| Clone | [5H7] |
| Host Species | Mouse |
| Reactive Species | human |
| Isotype | IgG2b |
| Format | Protein G purified |
| Size | 0.1 mL |
| Concentration | n/a |
| Applications | Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Specificity: Specific for endogenous levels of the ~85 kDa EWS protein. The Ewing Sarcoma Breakpoint Region 1 (EWSR1) gene encodes the EWS protein, which along with FUS and TAF15 comprises the FET family of RNA-binding proteins. EWS is primarily expressed in the nucleus, but has also been found in the cytoplasm of secretory cell types (Andersson et al., 2008). Defects of EWSR1 are known to cause Ewing sarcoma and have been implicated in amyotrophic lateral sclerosis (ALS) (Svetoni et al., 2016). Recently, EWS has been shown to directly interact with oncogenic ETS transcription factors in the promotion of prostate cancer (Kedage et al., 2016). |
| Immunogen | Immunogen Species: Human. Immunogen Information: Full length recombinant human EWS expressed in and purified from E Coli. |
| Other Names | [RNA-binding protein EWS isoform 3; RNA-binding protein EWS; RNA-binding protein EWS; EWS RNA binding protein 1; EWS oncogene; Ewing sarcoma breakpoint region 1 protein], [EWSR1] |
| Gene, Accession # | [EWS], Gene ID: 2130, NCBI: NP_001156757.1, UniProt: Q01844 |
| Catalog # | MBS500070 |
| Price | $360 |
| Order / More Info | EWS Antibody from MYBIOSOURCE INC. |
| Product Specific References | Andersson MK, Stahlberg A, Arvidsson Y, Olofsson A, Semb H, Stenman G, Nilsson O, Aman P (2008). The multifunctional FUS, EWS and TAF15 proto-oncoproteins show cell type-specific expression patterns and involvement in cell spreading and stress response. BMC Cell Biol. 11:9:37.Svetoni F, Frisone P, Paronetto MP (2016) Role of FET proteins in neurodegenerative disorders. RNA Biol. 2016 Nov;13(11):1089-1102Kedage V, Selvaraj N, Nicholas TR, Budka JA, Plotnik JP, Jerde TJ, Hollenhorst PC (2016) An Interaction with Ewing's Sarcoma Breakpoint Protein EWS Defines a Specific Oncogenic Mechanism of ETS Factors Rearranged in Prostate Cancer. Cell Rep. 2016 Oct 25;17(5):1289-1301. |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
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http://www.MyBioSource.com
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