Edit |   |
---|---|
Antigenic Specificity | PAK2 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | affinity purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | PAK2, also named as PAK65, PAKgamma, p58, PAK-2p27, PAK-2p24 and C-t-PAK2, belongs to the protein kinase superfamily, STE Ser/Thr protein kinase family and STE20 subfamily. PAK2 acts on a variety of targets. PAK2 catalyzes the reaction: ATP + a protein = ADP + a phosphoprotein. PAK2 phosphorylates ribosomal protein S6, histone H4 and myelin basic protein. Full length PAK 2 stimulates cell survival and cell growth. The process is, at least in part, mediated by phosphorylation and inhibition of pro-apoptotic BAD. Caspase-activated PAK-2p34 is involved in cell death response, probably involving the JNK signaling pathway. Cleaved PAK-2p34 seems to have a higher activity than the CDC42-activated form. The antibody has no cross reaction to PAK1 a |
Immunogen | Immunogen: Recombinant protein of human PAK2 Storage Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Other Names | [PAK65; PAKgamma] |
Gene, Accession # | [PAK2], Gene ID: 5062, NCBI: NP_002568.2, UniProt: Q13177 |
Catalog # | MBS8500228 |
Price | $310 |
Order / More Info | PAK2 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |