Edit |   |
---|---|
Antigenic Specificity | TOK-1 alpha |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | antigen affinity purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | Western Blot (WB), Immunofluorescence (IF) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | This gene product was isolated on the basis of its interaction with BRCA2 and p21 proteins. It is an evolutionarily conserved nuclear protein with multiple interacting domains. The N-terminal half shares moderate homology with regions of calmodulin and M-calpain, suggesting that it may also bind calcium. Functional studies indicate that this protein may be an important cofactor for BRCA2 in tumor suppression, and a modulator of CDK2 kinase activity via p21. This protein has also been implicated in the regulation of BRCA2 and RAD51 nuclear focus formation, double-strand break-induced homologous recombination, and cell cycle progression. Multiple transcript variants encoding different isoforms have been described for this gene. [provided by R |
Immunogen | Immunogen Type: Peptide Immunogen Description: Synthetic peptide contain a sequence corresponding to a region within amino acids 181 and 233 (Q9P287) of BCCIP |
Other Names | [BRCA2 and CDKN1A-interacting protein isoform BCCIPalpha; BRCA2 and CDKN1A-interacting protein; BRCA2 and CDKN1A-interacting protein; BRCA2 and CDKN1A interacting protein; P21- and CDK-associated protein 1; Protein TOK-1] |
Gene, Accession # | [TOK-1 alpha], Gene ID: 56647, NCBI: NP_057651 |
Catalog # | MBS9401839 |
Price | $320 |
Order / More Info | TOK-1 alpha Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |