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Antigenic Specificity | PSEN1 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | peroxidase (HRP) conjugate |
Size | 0.05 mg, 0.1 mg |
Concentration | n/a |
Applications | ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). Requires the other members of the gamma-secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. Stimulates cell-cell adhesion though its association with the E-cadherin/catenin complex. Under conditions of apoptosis or calcium influx, cleaves E-cadherin promoting the disassembly of the E-cadherin/catenin complex and increasing the pool of cytoplasmic beta-catenin, thus negatively regulating Wnt signaling. May also play a r |
Immunogen | Immunogen: Recombinant human Presenilin-1 protein |
Other Names | [Presenilin-1; Protein S182; Presenilin-1 NTF subunit; Presenilin-1 CTF subunit; Presenilin-1 C; PSEN1; AD3; PS1; PSNL1] |
Gene, Accession # | [PSEN1], Gene ID: 5663, NCBI: NP_000012.1, UniProt: P49768 |
Catalog # | MBS7044490 |
Price | $160, $235 |
Order / More Info | PSEN1 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |