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Antigenic Specificity | Nicastrin |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | peptide affinity purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Nicastrin, in addition to presenilin, PEN2, and APH-1 forms the gamma-secretase protein complex, a membrane-bound aspartyl protease that can cleave certain proteins at peptide bonds buried within the hydrophobic environment of the lipid bilayer. This cleavage is responsible for a key step in signaling from several cell-surface receptors and is thought to be required for the generation of the neurotoxic amyloid peptides that are central to the pathogenesis of Alzheimer's disease. Like the tumor necrosis factor-a-converting enzyme (TACE) and the b-site cleavage enzyme (BACE) protease families, gamma-secretase will cleave the amyloid precursor protein (APP), but within the intramembrane region of APP, resulting in either the non-toxic p3 (from |
Immunogen | Immunogen Type: Peptide Immunogen Description: Raised against a 17 amino acid peptide from near the carboxy terminus of human Nicastrin. |
Other Names | [Anterior pharynx defective 2, APH-2] |
Gene, Accession # | Gene ID: 23385, NCBI: NP_056146 |
Catalog # | MBS9410030 |
Price | $320 |
Order / More Info | Nicastrin Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |