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Antigenic Specificity | TNFSF10 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | antigen affinity purified |
Size | 0.06 mL, 0.12 mL, 0.2 mL |
Concentration | 1mg/mL |
Applications | Western Blot (WB), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL), also referred to as Apo2 ligand, first identified based on its sequence homology to TNF and Fas/Apo ligand is a member of the TNF family of cytokines and either exists as a type II membrane or soluble protein (1, 2). TRAIL induces apoptosis in a variety of transformed cell lines and plays a role in anti-tumor and anti-viral immune surveillance (3). TRAIL signals via binding with death receptors DR4 (TRAIL-R1) (4) and DR5 (TRAIL-R2) (5-8) which can trigger apoptosis as well as NF-kappaB activation (7, 9). Death domains on these receptors leads to the recruitment of a death-induced signaling complex (DISC) leading to caspase-8 and subsequent caspase-3 activation. In additi |
Immunogen | Immunogen: A synthetic peptide of human TNFSF10 Observed Molecular Weight: 33kDa |
Other Names | [APO2L; Apo-2L; CD253; TL2; TRAIL] |
Gene, Accession # | [TNFSF10], Gene ID: 8743, NCBI: CAG33176.1, UniProt: Q6IBA9 |
Catalog # | MBS2517946 |
Price | $150, $225, $360 |
Order / More Info | TNFSF10 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |