Edit |   |
---|---|
Antigenic Specificity | EP300 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | fluorescein (FITC) conjugate |
Size | 0.05 mg, 0.1 mg |
Concentration | n/a |
Applications | ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Functions as histone acetyltransferase and regulates transcription via chromatin remodeling. Acetylates all four core histones in nucleosomes. Histone acetylation gives an epigenetic tag for transcriptional activation. Mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. Mediates acetylation of histone H3 at 'Lys-122' (H3K122ac), a modification that localizes at the surface of the histone octamer and stimulates transcription, possibly by promoting nucleosome instability. Mediates acetylation of histone H3 at 'Lys-27' (H3K27ac). Also functions as acetyltransferase for nonhistone targets. Acetylates 'Lys-131' of ALX1 and acts as its coactivator. Acetylates SIRT2 and is proposed to indirectly increase the trans |
Immunogen | Immunogen: Recombinant human Histone acetyltransferase p300 protein |
Other Names | [Histone acetyltransferase p300; E1A-associated protein p300; EP300; P300] |
Gene, Accession # | [EP300], Gene ID: 2033, NCBI: NP_001420.2, UniProt: Q09472 |
Catalog # | MBS7043749 |
Price | $160, $235 |
Order / More Info | EP300 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |