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Antigenic Specificity | FRS2 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | affinity purified |
Size | 0.03 mg, 0.1 mg |
Concentration | 0.5 mg/ml |
Applications | Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Background: Fibroblast growth factor receptor substrate 2 (FRS2) is a 70-90kDA member of the FSR family of lipid-anchored docking protein. FRS2 contains Grb2 binding sites, a myristylation sequence and a PTP domain. Activation of FGFR leads to tyrosine phosphorylation of FRS2 and the binding of phosphorylated FRS2 to GRB2/SOS complexes. Once phosphorylated, FRS2 recruits SH2 domain-containing proteins including Grb2 and SHP-2 mediating downstream signalling. FRS2 thus, acts as an intermediary between FGF and Trk receptors that links receptor tyrosine kinase to Ras/MAPK signaling pathway. |
Immunogen | Immunogen: Synthetic peptide surrounding amino acid 493 of human FRS2 |
Other Names | [FRS2; FRS2A; FRS2alpha; SNT; SNT-1; SNT], [FRS2; FRS2; SNT; SNT1; FRS2A; SNT-1; FRS2alpha; FGFR substrate 2; SNT-1] |
Gene, Accession # | [FRS2], Gene ID: 10818, NCBI: NP_006645.3 |
Catalog # | MBS840232 |
Price | $150, $290 |
Order / More Info | FRS2 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |