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Antigenic Specificity | LRP6 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | antigen affinity purified |
Size | 0.1 mL |
Concentration | 3.9 mg/ml |
Applications | Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | The antibody detects endogenous levels of total LRP6 protein. This gene encodes a member of the low density lipoprotein (LDL) receptor gene family. LDL receptors are transmembrane cell surface proteins involved in receptor-mediated endocytosis of lipoprotein and protein ligands. The protein encoded by this gene functions as a receptor or, with Frizzled, a co-receptor for Wnt and thereby transmits the canonical Wnt/beta-catenin signaling cascade. Through its interaction with the Wnt/beta-catenin signaling cascade this gene plays a role in the regulation of cell differentiation, proliferation, and migration and the development of many cancer types. This protein undergoes gamma-secretase dependent RIP- (regulated intramembrane proteolysis) pro |
Immunogen | Immunogen: Synthetic peptide of human LRP6 |
Other Names | [ADCAD2] |
Gene, Accession # | [LRP6], Gene ID: 4040, NCBI: NP_002327.2, UniProt: O75581 |
Catalog # | MBS9415745 |
Price | $255 |
Order / More Info | LRP6 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |