AGER(RAGE) Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | AGER(RAGE) |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, mouse, rat |
| Isotype | n/a |
| Format | peptide affinity purified |
| Size | 0.1 mL, 0.2 mL |
| Concentration | 1mg/ml |
| Applications | Western Blot (WB), Immunohistochemisty (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC), ELISA (EIA) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Specificity: AGER(RAGE) antibody detects endogenous levels of total AGER(RAGE). Function: Mediates interactions of advanced glycosylation end products (AGE). These are nonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes. Acts as a mediator of both acute and chronic vascular inflammation in conditions such as atherosclerosis and in particular as a complication of diabetes. AGE/RAGE signaling plays an important role in regulating the production/expression of TNF-alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes. Interaction with S100A12 on endothelium, mononuclear phagocytes, and lymphocytes triggers cellular activation, with generation of key proinfl |
| Immunogen | Immunogen: A synthesized peptide derived from human AGER(RAGE) Subcellular Location: Secreted and Cell Membrane. Tissue Specificity: Endothelial cells. Predicted Cross Reactivity: Pig, Bovine, Horse, Sheep, Rabbit, Dog Similarity: Pig (92%), Bovine (83%), Horse (83%), Sheep (83%), Rabbit (100%), Dog (83%) |
| Other Names | [Advanced glycosylation end product-specific receptor; Ager; MGC2235; RAGE_HUMAN; Receptor for advanced glycosylation end products] |
| Gene, Accession # | [AGER], Gene ID: 177, NCBI: NP_001127.1, UniProt: Q15109 |
| Catalog # | MBS9601481 |
| Price | $240, $280 |
| Order / More Info | AGER(RAGE) Antibody from MYBIOSOURCE INC. |
| Product Specific References | Wu CZ, Zheng JJ, Bai YH, Xia P, Zhang HC, Guo Y; Journal: Onco Targets Ther. HMGB1/RAGE axis mediates the apoptosis, invasion, autophagy, and angiogenesis of the renal cell carcinoma. |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
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